Study of conversion of a food colouring agent revealed that neutralization of this xenobiotic takes place only in one phase - microsomal oxydation. Name a component of this phase:

A. Cytochrome C

B. Cytochrome B

C. Cytochrome A

D. Cytochrome Р-450

E. Cytochrome oxidase

 154 Study of fingerprints (dactylography) is used by criminalists for personal identification as well as for diagnostics of genetic abnormalities, particularly Dawn's diseas E. What layer of skin determines individuality of fingerprints?

A. Reticular

B. Horny

C. Dermopapillary

D. Clear (stratum lucidum epidermidis)

E. Basal

A 23 year old man has perforation of hard palat E. In the area of this perforation there was a compact well-defined formation. Microscopic examination of the resected formation revealed a large focus of caseous necrosis surrounded by granulation tissue with endovasculitis, cellular infiltration composed of lymphocytes, epithelioid cells (mainly plasmocytes). What is the most probable diagnosis?

A. Scleroma

B. Sarcoma

C. Tuberculosis

D. Syphilis

E. Leprosy

A clinic observes a 49 year old patient with significant prolongation of coagulation time, gastrointestinal haemorrhages, subcutaneous hematomas. These symptoms might be explained by the deficiency of the following vitamin:

A. E

B. H

C. B6

D. B1

E. K

 157 A doctor revealed tissues injury on patient's scalp with localized suppurations and diagnosed his disease as myiasis. This infestation is caused by larvae of the following insect:

A. Malarial mosquito

B. Kissing bug

C. Wohlfahrt fly

D. Mosquito

E. Stable fly (Stomoxys calcitrans)

A 4 year old child was admitted to the orthopaedic department with shin fracture together with displacement. Bone fragments reposition requires preliminary analgesi A. What preparation should be chosen?

A. Morphine hydrochloride

B. Promedol

C. Panadol

D. Analgin

E. -

Emotional stress causes activation of hormon-sensitive triglyceride lipase in the adipocytes. What secondary mediator takes part in this process?

A. Diacylglycerol

B. Ions of Са2+

C. Cyclic guanosine monophosphate

D. Cyclic adenosine monophosphate

E. Adenosine monophosphate

A patient suffering from periodical attacks caused by inhalation of different flavoring substances was diagnosed with atopic bronchial asthm A. IgE level was increase D. This is typical for the following type of reactions:

A. Anaphylactic reactions

B. delayed-type hypersensitivity

C. Cytotoxic reactions

D. Immunocomplex reactions

E. Autoimmune reactions

Researchers of a bacteriological laboratory examine tinned meat for botulinic toxin. For this purpose a group of mice was injected with an extract of the material under examination and antitoxic antibotulinic serum of A, B, E types. A control group of mice was injected with the same extract but without antibotulinic serum. What serological reaction was applied?

A. Precipitation

B. Neutralization

C. Opsonocytophagic

D. Complement binding

E. Double immune diffusion

Cardinal symptoms of primary hyperparathyroidism are osteoporosis and renal lesion along with development of urolithiasis. What substance makes up the basis of these calculi in this disease?

A. Uric acid

B. Bilirubin

C. Cystine

D. Cholesterol

E. Calcium phosphate

A 45 year old man consulted a doctor about a plaque-like formation on his neck. Histological examination of a skin bioptate revealed clusters of round and oval tumour cells with a narrow border of basophilic cytoplasm resembling of cells of basal epidermal layer. What tumour is it?

A. Epidermal cancer

B. Basal cell carcinoma

C. Hydroadenoma

D. Syringoadenoma

E. Trichoepithelioma

A cell at the stage of mitosis anaphase was stimulated by colchicine that inhibits chromosome separation to the poles. What type of mutation will be caused?

A. Duplication

B. Inversion

C. Translocation

D. Polyploidy

E. Deletion

Hours after tuberculine test (Mantoux test) a child had a papule 10 mm in diameter on the spot of tuberculine injection. What hypersensitivity mechanism underlies these changes?

A. Anaphylaxy

B. Granulomatosis

C. Cellular cytotoxicity

D. Immunocomplex cytotoxicity

E. Antibody-dependent cytotoxicity

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