Results: Hb- 80 g/l. Microscopical examination results: erythrocytes are of modified form. This
Condition might be caused by:
A Sickle-cell anemia
B Hepatocellular jaundice
C Acute intermittent porphyria
D Obturative jaundice
E Addison's disease
47
A 48 year old patient complained about intense pain, slight swelling and reddening of skin over
the joints, temperature rise up to 38oC. Blood analysis revealed high concentration of
Urates. This condition might be caused by disturbed metabolism of:
A Purines
B Collagen
C Cholesterol
D Pyrimidines
E Carbohydrates
48
A patient has yellow skin colour, dark urine, dark-yellow feces. What substance will have
Strengthened concentration in the blood serum?
A Unconjugated bilirubin
B Conjugated bilirubin
C Mesobilirubin
D Verdoglobin
E Biliverdin
49
A patient has an increased pyruvate concentration in blood. A large amount of it is excreted with
The urine. What vitamin is lacking in this patient?
A B1
B E
C B3
D B6
E B2
50
Ammonia is a very toxic substance, especially for nervous system. What substance takes the
Most active part in ammonia detoxication in brain tissues?
A Glutamic acid
B Lysine
C Proline
D Histidine
E Alanine
51
A patient has pellagra. Interrogation revealed that he had lived mostly on maize for a long time
And eaten little meat. This disease had been caused by the deficit of the following substance in
The maize:
A Tryptophan
B Tyrosine
C Proline
D Alanine
E Histidine
52
Increased production of thyroidal hormones T3 and T4, weight loss, tachycardia,
Psychic excitement and so on present on thyrotoxicosis. How do thyroidal hormones effect
Energy metabolism in the mitochondrion of cells?
A Disconnect oxidation and oxidated phosphorylation
B Activates phosphorylation of substance
C Stops phosphorylation of substance
D Stops respiratory chain
E Activates oxidated phosphorylation
53
A patient with high rate of obesity was advised to use carnitine as a food additive in order to
enhance "fat burning". What is the role of carnitine in the process of fat oxidation?
A Transport of FFA (free fatty acids) from cytosol to the mitochondria
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B Transport of FFA from fat depots to the tissues
C It takes part in one of reactions of FFA beta-oxidation
D FFA activation
E Activation of intracellular lipolysis
54
An experimantal animal that was kept on protein-free diet developed fatty liver infiltration, in
Particular as a result of deficiency of methylating agents. This is caused by disturbed generation
Of the following metabolite:
A Choline
B DOPA
C Cholesterol
D Acetoacetate
E Linoleic acid
55
A patient consulted a doctor about symmetric dermatitis of open skin areas. It was found out
That the patient lived mostly on cereals and ate too little meat, milk and eggs. What vitamin
Deficiency is the most evident?
A Nicotinamide
B Calciferol
C Folic acid
D Biotin
E Tocopherol
56
A 46 year old woman suffering from chololithiasis developed jaundice. Her urine became
Dark-yellow and feces became colourless. Blood serum will have the highest concentration of
The following substance:
A Conjugated bilirubin
B Unconjugated bilirubin
C Biliverdin
D Mesobilirubin
E Urobilinogen
57
A 46 year old patient applied to a doctor complaining about joint pain that becomes stronger the
Day before weather changes. Blood examination revealed strengthened concentration of uric
Acid. The most probable cause of the disease is the intensified disintegration of the following
Substance:
A Adenosine monophosphate
B Cytidine monophosphate
C Uridine triphosphate
D Uridine monophosphate
E Thymidine monophosphate
58
A 42-year man suffering from gout has increased level of urinary acid in the blood. Allopurinol
Was prescribed to decrease the level of urinary acid. Competitive inhibitor of what enzyme is
Allopurinol?
A Xanthinoxidase
B Adenosinedeaminase
C Adeninephosphoribosiltransferase
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D Hypoxantinphosphoribosiltransferase
E Guaninedeaminase
59
A 38 year old patient suffers from rheumatism in its active phase. What laboratory
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