The basic biochemical processes occurring in a nervous tissue.



In brain tissue, especially in neurons, during the life of the animal is very active redox processes associated with the release of energy. Unlike many organs, particularly the muscles, brain tissue is not dominated by the processes of glycolysis and aerobic oxidation of glucose, which is the main source of energy to CO2 and H2O. Therefore, the brain cells actively absorb oxygen delivered by the blood. So, in a calm state oxygen uptake by the brain is almost 20 times higher than muscle tissue. Brain and nerves consume about 20-25% of the oxygen utilized by the body. This feature explains the high sensitivity of the brain to a lack of oxygen (hypoxia). With the introduction of the drug decreases oxygen consumption by the brain - there is a general depression of vital activity of the nervous tissue.

Study of the conditions of inhibition of brain activity of animals is of considerable practical importance. Mechanized factories the most common way to pre-slaughter stunning of animals electrocution. In recent years, the practice of pig processing method includes gas stunning. For this purpose the short-term (40-50 s) of inhaled carbon dioxide or a mixture of C02 and X02. This disturbed the normal gas exchange, inhibited oxidative biochemical processes drastically reduced excitability, ie, observed inhibition of nervous tissue.

In addition the oxidation of glucose in the brain may also oxidation of glycogen. When this occurs it decay to a considerable extent by phosphorolysis and advantageously by hydrolysis with amylase.

Major energy-rich substances that accumulate in the nervous tissue in the oxidation of glucose - LTP and creatine - spent a considerable amount of nervous excitement.


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