Study of conversion of a food colouring agent revealed that neutralization of this xenobiotic



Takes place only in one phase - microsomal oxydation. Name a component of this phase:

A Cytochrome Р -450

B Cytochrome B

C Cytochrome C

D Cytochrome A

E Cytochrome oxidase

      178

A patient had hemorrhagic stroke. Blood examination revealed strengthened kinin

Concentration.The patient was prescribed contrical. It was administered in order to inhibit the

Following proteinase:

A Kallikrein

B Pepsin

C Trypsin

D Chemotrypsin

E Collagenase

      179

A 49-year-old driver complains about unbearable constricting pain behind the breastbone

Irradiating to the neck. The pain arose 2 hours ago. Objectively: the patient’s condition is grave,

He is pale, heart tones are decreased. Laboratory studies revealed high activity of creatine

kinase and LDH1. What disease are these symptoms typical for?

A Acute myocardial infarction

B Acute pancreatitis

C Stenocardia

D Cholelithiasis

E Diabetes mellitus

      180

Plasmic factors of blood coagulation are exposed to post-translational modification with the

Participation of vitamin K. It is necessary as a cofactor in the enzyme system of

$\gamma$-carboxylation of protein factors of blood coagulation due to the increased affinity of

Their molecules with calcium ions. What amino acid is carboxylated in these proteins?

A Glutamic

B Valine

C Serine

D Phenylalanine

E Arginine

      181

Pharmacological effects of antidepressants are connected with inhibition of an enzyme

Catalyzing biogenic amines noradrenaline and serotonine in the mitochondrions of cerebral

Neurons. What enzyme participates in this process?

A Monoamine oxidase

B Transaminase

C Decarboxylase

D Peptidase

E Lyase

      182

An oncological patient was prescribed methotrexate. With the lapse of time target cells of the

Tumour lost susceptibility to this drug. There is change of gene expression of the folowing

Enzyme:

A Dehydrofolate reductase

B Thiaminase

C Deaminase

D Folate oxidase

E Folate decarboxylase

183

Pterin derivatives (aminopterin and methotrexate) are the inhibitors of dihydrofolate reductase,

So that they inhibit the regeneration of tetrahydrofolic acid from dihydrofolate. These drugs

Inhibit the intermolecular tranfer of monocarbon groups, thus suppressing the synthesis of the

Following polymer:

A DNA

B Protein

C Homopolysaccharides

D Gangliosides

E Glycosaminoglycans

184

Hemoglobin catabolism results in release of iron which is transported to the bone marrow by a

Certain transfer protein and used again for the synthesis of hemoglobin. Specify this transfer

Protein:

A Transferrin (siderophilin)

B Transcobalamin

C Haptoglobin

D Ceruloplasmin

E Albumin

185

Electrophoretic study of a blood serum sample, taken from the patient with pneumonia, revealed

An increase in one of the protein fractions. Specify this fraction:

A γ -globulins

B Albumins

C α 1 -globulins

D α 2 -globulins

E β -globulins

186

Some infectious diseases caused by bacteria are treated with sulfanilamides which block the

Synthesis of bacteria growth factor. What is the mechanism of their action?

A They are antivitamins of para-amino benzoic acid

B They inhibit the absorption of folic acid

C They are allosteric enzyme inhibitors

D They are involved in redox processes

E They are allosteric enzymes

187

A 42-year-old male patient with gout has an increased blood uric acid concentration. In order to

Reduce the level of uric acid the doctor administered him allopurinol. Allopurinol is the competitive

Inhibitor of the following enzyme:

A Xanthine oxidase

B Adenosine deaminase

C Adenine phosphoribosyltransferase

D Hypoxanthine-phosphoribosyltransferase

E Guanine deaminase

188

A patient with jaundice has high total bilirubin that is mainly indirect (unconjugated), high

Concentration of stercobilin in the stool and urine. The level of direct (conjugated) bilirubin in the

Blood plasma is normal. What kind of jaundice can you think of?

A Hemolytic

B Parenchymal (hepatic)

C Mechanical

D Neonatal jaundice

E Gilbert's disease

189


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